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IN VITRO METABOLISM STUDY OF 3′-OH-2,4-diBDE-7 IN RAT LIVER S9 FRACTION

Zongwei Cai

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Abstract

Polybrominated diphenyl ethers(PBDEs) are an important class of brominated flame retardants that have been widely used in industrial and consumer products.PBDEs have become worldwide environmental pollutants because of the bioaccumulation,long-distance transportation and potential biological toxicities.Hydroxylated polybrominated diphenyl ethers(OH-PBDEs) are a relatively new group of phenolic compounds that have attracted particular interest due to their endocrine disrupting potency.OH-PBDEs are similar to PBDEs in chemical structure,but were reported to show stronger biological effects.In this study,we investigated in vitro metabolic behaviors of selected 3′-OH-BDE-7 in rat liver S9 fraction.The obtained results indicated that 2,4-dibromophenol and diOH-PBDEs were the major metabolites of OH-PBDEs.It′s worth noting that the hydroquinone like metabolites might pose a potential health risk to human and wild animals.

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What this paper is about

Polybrominated diphenyl ethers(PBDEs) are an important class of brominated flame retardants that have been widely used in industrial and consumer products.PBDEs have become worldwide environmental pollutants because of the bioaccumulation,long-distance transportation and potential biological toxicities.Hydroxylated polybrominated diphenyl ethers(OH-PBDEs) are a relatively new group of phenolic compounds that have attracted particular interest due to their endocrine disrupting potency.OH-PBDEs are similar to PBDEs in chemical structure,but were reported to show stronger biological effects.In this study,we investigated in vitro metabolic behaviors of selected 3′-OH-BDE-7 in rat liver S9 fraction.The obtained results indicated that 2,4-dibromophenol and diOH-PBDEs were the major metabolites of OH-PBDEs.It′s worth noting that the hydroquinone like metabolites might pose a potential health risk to human and wild animals.

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Available abstract

Polybrominated diphenyl ethers(PBDEs) are an important class of brominated flame retardants that have been widely used in industrial and consumer products.PBDEs have become worldwide environmental pollutants because of the bioaccumulation,long-distance transportation and potential biological toxicities.Hydroxylated polybrominated diphenyl ethers(OH-PBDEs) are a relatively new group of phenolic compounds that have attracted particular interest due to their endocrine disrupting potency.OH-PBDEs are similar to PBDEs in chemical structure,but were reported to show stronger biological effects.In this study,we investigated in vitro metabolic behaviors of selected 3′-OH-BDE-7 in rat liver S9 fraction.The obtained results indicated that 2,4-dibromophenol and diOH-PBDEs were the major metabolites of OH-PBDEs.It′s worth noting that the hydroquinone like metabolites might pose a potential health risk to human and wild animals.

Key concepts: Polybrominated diphenyl ethers, Bioaccumulation, Environmental chemistry, Chemistry, S9 fraction, Pollutant, Polybrominated Biphenyls, Microsome

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IN VITRO METABOLISM STUDY OF 3′-OH-2,4-diBDE-7 IN RAT LIVER S9 FRACTION — Research Paper | ScholarLens