2001•Unpublished venueRequires access

The Effect of bFGF on the Expression of HSP70 and Apoptosis in Rat Brain Following Cerbral Ischemia-reperfusion

Etang Tong

Abstract

Objective To study the effect of exogenous bFGF on the cell apoptosis through the expression of HSP70.Methods the effect of exogenous bFGF on HSP70 protein expression was examined via immunohistochemistry,at 1 72 h reperfusion after the Middle cerebral artery (MCA) was occluded for 2 h in rats. Simutaneously,the distribution of apoptosis was observed.Results The expression of HSP70 elevated and cell apoptosis decreased in bFGF treated rats as compared with ischemia rats(P0 05,P0 01).Conclusions Exogenous bFGF may induce HSP70 expression and supress apoptosis.

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Key concepts: Hsp70, Apoptosis, Ischemia, Immunohistochemistry, Reperfusion injury, Internal medicine, Endocrinology, Medicine