ScholarLens Back to search
2007•Linchuang gandanbing zazhiRequires access

Correlations of serum Pre-S_1 and HBeAg and HBV DNA in patients with chronic hepatitis B

Feng Jinhu

Open publisher page 0 citations

Abstract

Objective To investigate the correlations of serum pre-S_1 and HBeAg and HBV DNA in patients with chronic hepatitis B. Methods 651 patients with chronic hepatitis B were included in the study. Serum samples were detected with the quantitative determination of HBV DNA by a quantitative PCR assay and detemination of pre-S_1 protein by ELISA. Results The positive rates of HBV DNA and pre-S1 protein in patients with HBsAg/HBeAg/anti-HBc positive were 98.5%and 97.0%,respectively; in patients with HBsAg/anti-HBe/anti-HBc positive were 63.0%and 62.4%,respectively; in patients with HBsAg/anti-HBc positive were 49.1% and 45.4%,respectively. In samples with HBVDNA≥103copies /ml,the positive rate of HBeAg and pre-S1 were 34.1%and 95.7%,while in sera with HBV DNA103copies/ml,the positive rate of HBeAg and pre-S_1 were 0.9% and 2.4%.Conclusion Pre-S_1 is more sensitive than HBeAg in diagnosing viral replication in patients with chronic hepatitis B.

About this research paper

What this paper is about

Objective To investigate the correlations of serum pre-S_1 and HBeAg and HBV DNA in patients with chronic hepatitis B. Methods 651 patients with chronic hepatitis B were included in the study. Serum samples were detected with the quantitative determination of HBV DNA by a quantitative PCR assay and detemination of pre-S_1 protein by ELISA. Results The positive rates of HBV DNA and pre-S1 protein in patients with HBsAg/HBeAg/anti-HBc positive were 98.5%and 97.0%,respectively; in patients with HBsAg/anti-HBe/anti-HBc positive were 63.0%and 62.4%,respectively; in patients with HBsAg/anti-HBc positive were 49.1% and 45.4%,respectively. In samples with HBVDNA≥103copies /ml,the positive rate of HBeAg and pre-S1 were 34.1%and 95.7%,while in sera with HBV DNA103copies/ml,the positive rate of HBeAg and pre-S_1 were 0.9% and 2.4%.Conclusion Pre-S_1 is more sensitive than HBeAg in diagnosing viral replication in patients with chronic hepatitis B.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To investigate the correlations of serum pre-S_1 and HBeAg and HBV DNA in patients with chronic hepatitis B. Methods 651 patients with chronic hepatitis B were included in the study. Serum samples were detected with the quantitative determination of HBV DNA by a quantitative PCR assay and detemination of pre-S_1 protein by ELISA. Results The positive rates of HBV DNA and pre-S1 protein in patients with HBsAg/HBeAg/anti-HBc positive were 98.5%and 97.0%,respectively; in patients with HBsAg/anti-HBe/anti-HBc positive were 63.0%and 62.4%,respectively; in patients with HBsAg/anti-HBc positive were 49.1% and 45.4%,respectively. In samples with HBVDNA≥103copies /ml,the positive rate of HBeAg and pre-S1 were 34.1%and 95.7%,while in sera with HBV DNA103copies/ml,the positive rate of HBeAg and pre-S_1 were 0.9% and 2.4%.Conclusion Pre-S_1 is more sensitive than HBeAg in diagnosing viral replication in patients with chronic hepatitis B.

Key concepts: HBeAg, Medicine, HBsAg, Chronic hepatitis, Virology, Hepatitis B, Gastroenterology, Hepatitis B virus

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Correlations of serum Pre-S_1 and HBeAg and HBV DNA in patients with chronic hepatitis B — Research Paper | ScholarLens