Influences of modified Jiegeng Tang on content of neuropeptides in lung and intestines in mice with slow transit constipation

Objective To observe the influences of Chinese medicinals with actions of dispersing lung(modified Jiegeng Tang) on investine transmission function and content of neurokinin A(NKA) and vasoactive intestinal peptide(VIP) in lung and intestine in mice with slow transit constipation(STC),and discuss the connecting mechanism of lung associating with large intestine from the angle of neuropeptides.Methods Mice(n=40) were randomly divided into normal group,model group,model treatment group and normal treatment group.STC model was established with the intragastrical method combining self-feces and compound diphenoxylate.Model treatment group and normal treatment group were given modified Jiegeng Tang intragastrically for 7 days,and normal group and model group was given distilled water intragastrically for 7 days.The defecation of mice was observed and content of NKA and VIP were detected in lung and intestine.Results Compared with normal group,in model group the time of the first melena was prolonged,number and weight of 4-hour melena decreased significantly,and NKA increased significantly and VIP decreased significantly in lung and intestine.Compared with model group,in model treatment group the time of the first melena was shortened,number and weight of 4-hour melena increased,and NKA decreased significantly in lung and intestine and VIP increased significantly in lung.Conclusion Modified Jiegeng Tang can improve the intestine transmission function in STC mice,and the mechanism may be related to the regulation of the content of NKA and VIP in lung and intestine.