ScholarLens Back to search
2006•Inner Mongolia Medical JournalRequires access

Effect of Valsartan on Diabetic Nephropathy

Wei Yun-xiang

Open publisher page 0 citations

Abstract

Objective:To survey the effect of angiotensin Ⅱ type 1 receptor antagonists(AT_1Ra) valsartan on diabetic nephropathy representing a great quantity of albuminuria.Methods:32 cases of diabetic in type 2 with hypertension and 24 urine albumine excretion rate(24h UAER) more than 200μg/min were selected and divided into two groups.Their conventional therapy for diabetes was maintained.The mean arterial pressure(MAP),24h UAER,HbA_1c and vric acid before and 8 weeks after administrating valsartan in dosage of 80 mg daily or benazeprin in dosage of 10mg daily were observed.Results:The 24h UAER decreased from 703.2±987.9 to 664.2±970.6μg/min in group with valsartan(P0.01),778.6±1005.0 to 734.9±996.0μg/min in group with benazeprin(P0.01).The curative effect of valsartan was similar to that of benazeplin,which was not associated with the change of blood pressure.Conclusion:Valsartan can reduce albuminuria in diabetic nephropathy,it's protection in kidney includes other mechanisms besides underpressure.

About this research paper

What this paper is about

Objective:To survey the effect of angiotensin Ⅱ type 1 receptor antagonists(AT_1Ra) valsartan on diabetic nephropathy representing a great quantity of albuminuria.Methods:32 cases of diabetic in type 2 with hypertension and 24 urine albumine excretion rate(24h UAER) more than 200μg/min were selected and divided into two groups.Their conventional therapy for diabetes was maintained.The mean arterial pressure(MAP),24h UAER,HbA_1c and vric acid before and 8 weeks after administrating valsartan in dosage of 80 mg daily or benazeprin in dosage of 10mg daily were observed.Results:The 24h UAER decreased from 703.2±987.9 to 664.2±970.6μg/min in group with valsartan(P0.01),778.6±1005.0 to 734.9±996.0μg/min in group with benazeprin(P0.01).The curative effect of valsartan was similar to that of benazeplin,which was not associated with the change of blood pressure.Conclusion:Valsartan can reduce albuminuria in diabetic nephropathy,it's protection in kidney includes other mechanisms besides underpressure.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective:To survey the effect of angiotensin Ⅱ type 1 receptor antagonists(AT_1Ra) valsartan on diabetic nephropathy representing a great quantity of albuminuria.Methods:32 cases of diabetic in type 2 with hypertension and 24 urine albumine excretion rate(24h UAER) more than 200μg/min were selected and divided into two groups.Their conventional therapy for diabetes was maintained.The mean arterial pressure(MAP),24h UAER,HbA_1c and vric acid before and 8 weeks after administrating valsartan in dosage of 80 mg daily or benazeprin in dosage of 10mg daily were observed.Results:The 24h UAER decreased from 703.2±987.9 to 664.2±970.6μg/min in group with valsartan(P0.01),778.6±1005.0 to 734.9±996.0μg/min in group with benazeprin(P0.01).The curative effect of valsartan was similar to that of benazeplin,which was not associated with the change of blood pressure.Conclusion:Valsartan can reduce albuminuria in diabetic nephropathy,it's protection in kidney includes other mechanisms besides underpressure.

Key concepts: Valsartan, Medicine, Albuminuria, Diabetic nephropathy, Urology, Blood pressure, Diabetes mellitus, Excretion

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Effect of Valsartan on Diabetic Nephropathy — Research Paper | ScholarLens