2006•Academic Journal of Second Military Medical UniversityRequires access
Detection of mycoplasma infection in human laryngeal carcinoma
Shuwei Zhao, Sun Baochun, Lang Jun-tian, Jie Qiu, He Jin, Qiang Bi, Haiqing Wang, Xinjiang Ying, Qing Ye, Aihua Sun
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Abstract
Objective:To detect and analyze the mycoplasma infection in human laryngeal carcinoma and to explore the relationship between the infection with the development,progression and prognosis of laryngeal cancer.Methods: Immunohistochemical methods were employed to detect the mycoplasma infection in 214 specimens of different laryngeal lesions and cervical lymphatic tumors metastasized from laryngeal cancer,including 121 laryngeal cancer specimens,21 laryngeal precancerous specimens,17 vocal cord polypus specimens,14 normal laryngeal tissues adjacent to cancer tissues,9 normal laryngeal tissues opposite to the cancer,and 32 cervical lymphatic tumor specimens metastasized from laryngeal cancer.The infection results were subjected to statistical analysis.Results: The positive rates of mycoplasma 2G10 antibody in laryngeal carcinoma specimens,cervical lymphatic tumor specimens metastasized from laryngeal cancer,laryngeal precancerous specimens,vocal cord polypus specimens,normal laryngeal tissues adjacent to cancer tissues,and normal laryngeal tissues opposite to the cancer were 44.63%(54/121),34.38%(11/32),23.81%(5/21),17.65%(3/17),7.14%(1/14),and 0%(0/9),respectively,with those of laryngeal carcinoma specimens and cervical lymphatic tumor specimens metastasized from laryngeal cancer significantly higher than those of other specimens(P0.05).The positive rate of early stage laryngeal carcinoma(ⅠⅡ stage,16.36%9/55) was significantly lower than that of advanced stage laryngeal carcinoma(Ⅲ-Ⅳ,68.18%45/66),(P0.01).The positive rate of laryngeal carcinoma with cervical metastasis was higher(62.50%20/32) than that without cervical metastasis(35.96%32/89),(P0.01).The 3-and 5-year survival rates of Ⅲ-Ⅳ stage patients positive of 2G10 antigen(60.0%27/45,58.14%25/43) were lower than those of patients negative of 2G10 antigen(85.71% 18/21,84.21%(16/19),(P0.05).Conclusion: Laryngeal carcinoma has a high infection rate of mycoplasma,which may be related with the development,progression and prognosis of laryngeal carcinoma.