Resistance analysis of Pseudomonas aeruginosa resisting to ciprofloxacin

Objective To investigate the medical resistance of P.aeruginosa resisting to ciprofloxacin. Methods 68 strains of ~P.aeruginosa resisting to ciprofloxacin were identified and performed the antibiotic sensitivity test by VITKE-2 system.The antibiotic included imipenem,amikacin,gentamycin,ceftazidime piperacillin,piperacillin/tazobactam.Analyze the medical resistance of 67 strains of P.aeruginosa sensitive to ciprofloxacin in contrast.Results The rate of sensitivity to these six kinds of antibiotics were imipenem 70.6%,amikacin 20.6%,gentamycin 19.1%,ceftazidime 27.9%,piperacillin 63.2%,piperacillin/tazobactam 72.1% respectively.These sensitivity rates were apparently lower than the rates of the strains of P.aeruginosa sensitive to ciprofloxacin which were 92.5%,32.8%,68.7%,65.6%,88.1% and 89.6% respectively.By chi-square test there were significant difference of five kinds of antibiotics(P0.05) except amikacin(P0.1) between two kinds of strains of P.aeruginosa.Conclusion Imipenem,piperacillin/tazobactan and piperacillin would had better effect in treating the infection aroused by P.aeruginosa resisting to ciprofloxacin,but amikacin,gentamycin and ceftazidime were not recommend.