A Meta-Analysis of Ureaplasma urealyticum,Ureaplasma parvum Infection and Male Nongonococcal Urethritis

Objective To investigate the correlation between Ureaplasma urealyticum, Ureaplasma parvum infection and male nongonococcal urethritis. Methods The studies on the relationship of ureaplasmas infection and male nongonococcal urethritis were collected by searching from Pubmed database,CBM database,CNKI database and so on(2000-2011), and analyzed by meta-analysis. The odds ratio was calculated by Review Manager 5.0 software. Results Nine studies accorded with research criteria including 1 687 cases and 1 386 controls were analyzed. The combined OR value of Ureaplasmas infection to male NGU was 1.09, 95% CI(0.80,1.47), the test for overall effect P=0.60.However, the OR value of UU infection to male NGU was 1.65, 95%CI(1.10,2.47), the test for overall effect P=0.02. But, contrary to UU, the OR value of UP infection to NGU was 0.57, 95%CI(0.45,0.72), the test for overall effect P0.000 01. Conclusion UU mainly exists in the NGU group, and has the higher virulence. However, UP is detected more frequently in the control group and may be the parasitic microorganism in the male urethra. So, it is important to detect separately Ureaplasma urealyticum and Ureaplasma parvum. It will have far-reaching influence for clinical diagnosis and epidemiological survey.