The effects of Diane-35 and metformin to the Leptin and insulin level of polycystic ovary syndrome(PCOS)

Objective: To evaluate levels of leptin in PCOS and note any relationships with insulin resistance and sex hormone.Investigate the effects of Diane-35 and metformin to the leptin and insulin level of women with PCOS and hyperinsulinemia.Methods: Fifty patients with PCOS and twenty age and body mass index-matched controls were included in the study.In all patients,serum concentration of leptin,fasting plasma glucose,fasting insulin,T,FSH and LH were measured to compare and investigate the relationship of leptin to insulin and sex hormone.Then divide the 26 women with PCOS and hyperinsulinmia into A and B groups.Group A were treated with Diane-35.Group B were treated with both Diane-35 and metformin.All were treated 3 months.Compare the changes of those indexes before and after the treatement.Results: Serum leptin,fasting insulin levels,LH/FSH,and T in PCOS were significantly higher than those in control group(P0.05),Serum leptin was positively correlated with BMI and fasting insulin(P0.05).Before treatment,age,BMI,Leptin,FINS,T,LH/FSH was not significant different between group A and B(P0.05).After treatment,(1) In group A,T,LH/FSH was significant lower(P0.05),the change of BMI,Leptin,FINS were not significant different(P0.05);(2) In group B,Leptin,FINS,T,LH/FSH were all significant lower(P0.05),though BMI decreased,but this change was not significant(P0.05);(3) FINS,T,LH/FSH in group B were significant lower than group A(P0.05).Conclusion: The leptin concentration is abnormal in PCOS women.Leptin is close related to insulin resistance and hyperinsulinmia in PCOS.Diane-35 combined with metformin can effectively decrease the levels of Leptin,FINS,T in women with PCOS and hyperinsulinmia,Its therapy result is better than only using Diane-35.