Servation on the Clinical Efficacy of Bronchoalveolar Lavage Combined with Sequential Mechanical Ventilation in the Treatment of COPD with Respiratory Failure

Objective To explore and analyze the clinical efficacy of bronchoalveolar lavage combined with invasive noninvasive mechanical ventilation sequential therapy in the treatment of chronic obstructive pulmonary disease( COPD) patients with respiratory failure. Method 100 cases of COPD complicated with respiratory failure patients from January 2011 to Decwmber 2013 in our hospital were selected according to the random number table,which were divided into observation group and control group,each group with 50 cases. The patients in control group were treated with invasive mechanical ventilation,while the observation group patients with the bronchoalveolar lavage therapy combined with sequential invasive-noninvasive mechanical ventilation therapy. Curative effect was observed and compared between the two groups after treatment. Result The infection correcting time,the total duration of mechanical ventilation,duration of hospitalization of patients with respiratory failure were significantly shorter than those of the control group; each index with blood gas analysis in the two groups after switching windows significantly changed,pH,and PaO2 of the observation group patients after switching time window were significantly higher than those of the control group,and the PaCO2 was significantly lower than that of the control group,and the two groups had significant difference( P 0. 05); the overall complication rate of the patients in observation group after treatment was 10%,significantly lower than that of the control group( 40%),with statistical significance( P 0. 05).Conclusion Bronchoalveolar lavage combined with sequential mechanical ventilation has significant curative effect in the treatment of COPD with respiratory failure,not only can effectively improve the symptoms of the COPD patients,control the infection,shorten the time of hospitalization,but also reduce the incidence of ventilator-associated pneumonia and other complications rate; therefore it is an effective means of treatment,which is worthy of putting into clinical application.