Omeprazole-based Triple Therapy for Treatment of Children with Peptic Ulcer

Objective To discuss the clinical effect and significance of omeprazole-based triple therapy in children with peptic ulcer.Methods 60 children with peptic ulcer in our hospital,were randomly divided into A,B two groups.Patients in the group A was given triple therapy of omeprazole,clarithromycin tablets and amoxicillin;while those in the group B received treatment of cimetidine,clarithromycin tablets and amoxicillin.Indexes including the total efficiency and Helicobacter pylori eradication rate of the two group was compared.Results Clearance rate of 86%is significantly better than other drugs group 72%the Helicobacter pylori A group with omeprazole based triple therapy using after treatment(P0.05);A group with omeprazole-based triple therapy after treatment,the total efficiency of 100%was significantly higher than that of conventional treatment and 96%in B group(P 0.05).Conclusion The application of omeprazole-based triple therapy for treatment of children with peptic ulcer can effectively improve the eradication of helicobacter pylori and shorten the treatment time,promote recovery,significantly reduce the relapse rate of the disease,inhibits gastric acid secretion and rapidly improve the erosion of gastric mucosa.