Clinical Significance of Combined Detection of AST/ALT Ratio and HBV Serological Markers in HBV Infected Patients

To detect the serum level of ALT,AST,AST/ ALT ratio and HBeAg in different stages of HBV related diseases,and to explore the relationship between them.The serum levels of ALT,AST and HBeAg in 296 HBV infected patients and 99 healthy controls were measured by using rate,and ELISA methods.The results showed that the HBeAg positive rate in chronic hepatitis B group(CHB) was higher than that of in liver cirrhosis(LC) and primary hepatic carcinoma(HCC) group.The anti-HBe positive rate in HCC group was higher than that of in LC and CHB group.The serum levels of ALT and AST in CHB,LC and HCC group were higher than that in control group.The AST/ALT ratio in CHB group was lower than that in control group,the AST/ALT ratio in LC and HCC group was higher than that in CHB and control group(P0.05).There was no significant difference between HBeAg-positive and Anti-HBe-positive patients on the serum levels of AST and AST/ALT ratio(P0.05).The area under the ROC curve of AST/ALT ratio in CHB group was 0.71,it was higher than that of ALT and AST.In LC group,the area under the ROC curve of AST was 0.664,it was higher than that of ALT and AST/ALT.In HCC group,area under the ROC curve of AST was 0.675,it was the highest.The serum level of AST and AST/ALT ratio were changed as the diseases developing after HBV infection.The HbeAg positive rate was gradually decreased,whereas anti-HBe positive rate was increased.It indicated that the hepatic injury was related with disturbances of body's immune system.The AST/ALT ratio could improve the clinical diagnosis of HBV related diseases.