Clinical research of combined detection of four indices,AST/ALT ratio,and hepatitis B DNA in diagnosis and treatment of liver cirrhosis after hepatitis

Objective To discuss the clinical application value of combined detection of four indices,AST/ALT ratio,and hepatitis B DNA in the diagnosis and treatment of liver cirrhosis after hepatitis.Methods 130 cases with posthepatitic cirrhosis of digestive system department from 2009 May to 2011 May in our hospital were selected.80 cases of chronic hepatitis B at the same time were chosen as control group.HA,PⅢNP,Ⅳ-Col,LN,ALT,AST,AST/ALT and HBV DNA level in the serum were detected.Results(1)HA,Ⅳ Col,PⅢNP,LN in serum of posthepatitic cirrhosis patients were significantly higher than that of simple chronic hepatitis B group(P0.01).(2)Four indices of liver fibrosis in serum of hepatitis B cirrhosis patients with HBV-DNA106 copy/mL,in addition to LN,the other indices levels were significantly higher than that in patients with HBV-DNA between 103-105 copy/ ml and patients with HBV-DNA 103 cop / ml.The difference was significant(P0.01).There was no significant difference in patients with HBV-DNA between 103-105copy/mL and patients with HBV-DNA 103 copy/ml(P0.05).(3)Among AST/ALT2,1AST/ALT2 and AST/ALT1 groups,the change of HA was most significant.HA gradually rose following AST/ALT ratio increased,each group has significant difference(P0.05).Col levels elevated in AST/ALT2 and AST/ALT1 groups,and there was significant difference(P0.05).PⅢNP and LN levels elevated in each group,but there was no significant difference(P0.05).Conclusion Combined detection of four indices,AST/ALT ratio,and hepatitis B DNA was useful for the detection of pathogenesis of patients with liver cirrhosis after hepatitis.And it can provide basis of antiviral and antifibrotic treatment in clinic.