2010•Zhongguo laonianxue zazhiRequires access
Effect of Zhiweifangbian capsule on activity of superoxide dismutase,glutathione peroxidase and content of malondialdehyde,lipid peroxidation in gastric tissue of rats with chronic atrophic gastritis
Li Wan
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Abstract
Objective To study effects of Zhiweifangbian capsule (ZWFB) on activity of glutathione peroxidase (GSH-Px),superoxide dismutase (SOD) and content of malondialdehyde (MDA),lipid peroxidation (LPO) in gastric tissue of rats with chronic atrophic gastritis (CAG).Methods CAG model was established with synthetic method.The effect of ZWFB on activity of SOD,GSH-Px and content of MDA,LPO in gastric tissue were observed.Results In successful model group,activity of SOD,GSH-Px were much lower than those of normal group (P0.01;P0.05),content of MDA,LPO were much higher than those of normal group (P0.01;P0.01).Compared with model group,ZWFB could increase activity of SOD,GSH-Px (P0.05;P0.05) and decrease content of MDA,LPO (P0.01;P0.05) significantly.Conclusions ZWFB has functions of elevating antioxidation enzyme activity,lessening free radical impairment and restraining lipid peroxidation.