Prognostic evaluation of PCNA and BCL-2 expression in colorectal carcinoma

Objective:To investigate the prognostic evaluation of PCNA and BCL-2 expression in patients with colorectal carcinoma.Methods:Utilizing sABC Immunohistochemical methods, PCNA and BCL-2 expression of specimens from patients with colorectal carcinoma during a three-year follow-up were analyzed.Results: PCNA and BCL-2 expression was negative in normal colorectal mucosae but positive in colorectal carcinoma. PCNA demonstrated a positive correlation ( P 0.05) with the recurrence and death time of patient, tumor stage and lymphatic metastasis, but a negative correlation with patient's age, gender and tumor location. BCL-2 only shared a highly positive correlation ( P 0.05)with tumor stage and no obvious correlation ( P 0.05) with such factors as recurrence time, death time, age, gender and tumor location.Conclusions:PCNA and BCL-2 expression analysis is of important value in clinical treatment and prognostic evaluation of colorectal carcinoma.