Clinical effects of Solifenacin combined with Tamsulosin in treating overactive bladder after transurethral resection prostate

Objectives: To study the clinical effect of Solifenacin combined with Tamsulosin in the treatment of overactive bladder after transurethral resection prostate(TURP).Methods: We selected 48 patients with overactive bladder after TURP in our hospital from January 2011 to June 2012.They were divided into control group and observation group randomly.The patients in the observation group were treated with 5mg of Solifenacin and 0.2mg of Tamsulosin orally once a day and the course lasts for seven to ten days.The patients in the control group only got indomethacin suppository,symptomatic treatment when they were in pain.We assessed the overactive bladder syndrome,the quality of life and the international prostate symptom of the two groups before and after the treatment to evaluate the therapeutic efficacy and side effects of the drugs.Results: All the patients finished the treatment in the inpatient department.For the observation group,the drug taking course is seven to ten days,8.5 days in average.The drug was suspended after the symptoms of frequent micturition and urinary incontinence disappear.Before receiving the treatment,there is no significant difference of the OABSS score,QOL score and IPSS score of the two groups.(P0.05) After treatment,the OABSS score,QOL score,IPSS score of observation group are significantly lower than those of the control group.(P0.05) The scores changed greatly before and after the treatment while there is no significant difference in the control group(P0.05).Only one patient of the observation group has dry mouth symptom,and without other adverse reactions such as the dizziness,constipation,headaches.The rest patients have no adverse reactions.Conclusions: Solifenacin combined with Tamsulosin can be adopted in the treatment of overactive bladder after transurethral resection prostate,and the curative effect is outstanding.It can significantly improve the bladder excessive symptom,having lower rate of adverse reactions.