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2008•Journal of Sun Yat-sen UniversityRequires access

Detection of Fetal SRY Gene Using Free Fetal DNA in Maternal Plasma

Hongli Xi

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Abstract

【Objective】 To establish a noninvasive method for detecting fetal SRY gene by free fetal DNA in maternal plasma.【Method】 We got free fetal DNA from maternal peripheral blood and amplified the SRY sequence to make sure the fetal gender,followed to verify the truth after birth.【Result】 Sixteen pregnant women were involved,10 out of 16 subjects were identified as 7 males and 3 females.Among them,9 ones were verified the truth with the postnatal test.1 subject could not be followed up.【Conclusion】The technique established in the study was reliable and the free fetal DNA can be used as the sample of noninvasive prenatal diagnosis for detecting sex-linked disorders and single gene disorders.

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What this paper is about

【Objective】 To establish a noninvasive method for detecting fetal SRY gene by free fetal DNA in maternal plasma.【Method】 We got free fetal DNA from maternal peripheral blood and amplified the SRY sequence to make sure the fetal gender,followed to verify the truth after birth.【Result】 Sixteen pregnant women were involved,10 out of 16 subjects were identified as 7 males and 3 females.Among them,9 ones were verified the truth with the postnatal test.1 subject could not be followed up.【Conclusion】The technique established in the study was reliable and the free fetal DNA can be used as the sample of noninvasive prenatal diagnosis for detecting sex-linked disorders and single gene disorders.

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Available abstract

【Objective】 To establish a noninvasive method for detecting fetal SRY gene by free fetal DNA in maternal plasma.【Method】 We got free fetal DNA from maternal peripheral blood and amplified the SRY sequence to make sure the fetal gender,followed to verify the truth after birth.【Result】 Sixteen pregnant women were involved,10 out of 16 subjects were identified as 7 males and 3 females.Among them,9 ones were verified the truth with the postnatal test.1 subject could not be followed up.【Conclusion】The technique established in the study was reliable and the free fetal DNA can be used as the sample of noninvasive prenatal diagnosis for detecting sex-linked disorders and single gene disorders.

Key concepts: Testis determining factor, Cell-free fetal DNA, Fetus, Gene, Obstetrics, DNA, Andrology, Prenatal diagnosis

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