Scanning electron microscope on cilia of nasal cavity mucosa by using ephedrine at different time

Objective To observe the effects of ephedrine on cilia of nasal cavity mucosa for the healthy New Zealand white rabbits at different time and provide scientific evidences for using ephedrine.Methods 80 New Zealand rabbits were used in the experiment.8 in control group and other 54 rabbits were divided into 9 groups.8 in every-group.3 groups(group A)used 1% ephedrine for 5days,another 3 groups(group B)used 1% ephedrine for 10 days,last 3 groups(group C)used 1% ephedrine for 20 days.All of the samples were obtained instantly and after 30,50 days respectively.All of the samples were observed with scanning electron microscope.Results Using ephedrine could make cilia of nasal cavity mucosa disorganization.Part of cilia of nasal cavity mucosa of group A were damaged and its recoverey needed 50 days.Most parts of cilia of nasal cavity mucosa of group B were damaged seriously and it was recovered partly after 50 days.All of cilia of nasal cavity mucosa of group C were damaged and nasal cavity mucosa was replaced by fibrous tissues.Conclusion The cilia of nasal cavity mucosa of New Zealand white rabbits can be damaged by ephedrine.But using ephedrine in short time cilia of nasal cavity mucosa can be recovered.