Detection and etiological analysis of specific IgE in serum of 120 patients with allergic purpura

Objective To detect serum levels of total IgE and specific IgE of patients with allergic purpura,and to investigate the components of the allergen,so as to provide laboratory basis for searching for cause and effective prevention of the disease.Methods 120 patients were examined for serum concentrations of total IgE and specific IgE by using ELISA. Results The sarum total IgE was positive(93.3%) in 112/120 and the serum allergen-specific IgE was positive in 103/120(85.5%).Of which,positive reaction to one kind of allergen was found in 42 cases(35%) and that to two or more than two allergens was found in 61 cases(50.8%);the most common allergen for specific IgE in inhalation allergen group was Herba Humuli(15%),the next was polyvalent fungi(mycete)(11.7%) and dust mite/food mite.In protein food allergen group,the most commom allergen was shrimp/crab(15.8),and the next was fish(10.8%) and egg(9.2%).In vegetable and fruit group,the most commom allergen was tomato/spinach/celery(14.2%),the next was beans/carrot/pumpkin and salad/lettuce/mushroom/cucumber(10%).Conclusion By detecting serum allergens of patients with allergic purpura using ELISA,it was found that in the positive rate of serum allergen,there was no significant difference,between inhalation group and food group,and the combined allergens were more common,which can provide a laboratory basis for diagnosis,effective prevention and treatment of allergic purpura according to allergens found.