The Clinical Significance of Troponin I in Patients with Unstable Angina

Objective To observe the changes of serum troponinⅠ(cTnI) in patients with unstable angina (UA) and evaluate the short-term and future predictive value for cardiac events.Methods Blood samples were obtained at admission,12,24,48 hours and 10 days later from 60 consecutive UA patient.Serum concentration of cTnI were measured by IMMULITE system automatically.The relations between the change of cTnI and cardiac events including AMI,sudden death and refractory angina were analyzed.Result The incidence of cardiac events with in 30 days was significantly higher in group with increased cTnI (≥0.4 ng/ml) than that with normal cTnI (0.4 ng/ml),(48.15% vs9.1%,P0.05),Within the 1 year follow-up,cardiac sudden death occurred in 5 patients (18.52%) of the cTnI≥0.4 ng/ml group,whereas only 1 (3.03%) of the cTnI0.4 ng/ml group (P0.05).Conclusion The present study suggests that serum cTnI level detected quantitatively show very important predictive value for chrdiac event in patients with unstable angina pectoris.