Characteristics of regional cerebral blood flow imagine in patients with vascular dementia

Objective To explore the change of cerebral blood flow in the patients with vascular dementia(VD). Methods Using single photon-emission computed tomography (SPECT) 99mTc-ECD, regional cerebral blood flow(rCBF)was quantitatively determined in the following 3 groups: VaMCI group(n=13),VD group(n=12)and NC group (control group of normal elderly subjects )(n=11).The characteristics of rCBF were analyzed quantitatively.Results The rCBF of frontal lobe , temporal lobes, parietal lobe and basal ganglia in VD and VaMCI groups was lower than that in NC group(P0.05).The rCBF of same lobes and basal ganglia in VD group was lower than that of patients with VaMCI,especially in frontal lobe and temporal lobe(P0.01).The rCBF of frontal lobe , temporal lobe , parietal lobe and basal ganglia was lower than that of NC(P0.05).There was a positive correlationship between rCBF of frontal lobe,parietal lobe and the data of MMSE(r=0.918,P0.01;r=0.76, P0.05). Conclusion SPECT is helpful for the diagnosis of the early stage of VD. SPECT rCBF imaging is beneficial to preventing and treating VD.It is also sensitive for detecting VaMCI.