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Expression and significance of p-AKT in NSCLC

SU Jun-mei

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Abstract

Objective To investigate the expression and significance of phosphor-AKT(p-AKT) in non-small cell lung cancer(NSCLC). Methods The expression of p-AKT was detected by immunohistochemistry in 52 cases of NSCLC and 18 normal lung tissue. Results The positive rates of p-AKT was 53.8% in NSCLC and 0.0 in normal lung tissue(P 0.05).The expression of p-AKT was not related to age,sex,smoking,histological subtype,grade of cell differentiation,lymph node metastasis and TNM stage(P0.05). Conclusion The expression of p-AKT was higher in NSCLC than in normal tissue.The PI3K/AKT signaling pathway may participate in carcinogenesis and development of NSCLC.

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What this paper is about

Objective To investigate the expression and significance of phosphor-AKT(p-AKT) in non-small cell lung cancer(NSCLC). Methods The expression of p-AKT was detected by immunohistochemistry in 52 cases of NSCLC and 18 normal lung tissue. Results The positive rates of p-AKT was 53.8% in NSCLC and 0.0 in normal lung tissue(P 0.05).The expression of p-AKT was not related to age,sex,smoking,histological subtype,grade of cell differentiation,lymph node metastasis and TNM stage(P0.05). Conclusion The expression of p-AKT was higher in NSCLC than in normal tissue.The PI3K/AKT signaling pathway may participate in carcinogenesis and development of NSCLC.

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Available abstract

Objective To investigate the expression and significance of phosphor-AKT(p-AKT) in non-small cell lung cancer(NSCLC). Methods The expression of p-AKT was detected by immunohistochemistry in 52 cases of NSCLC and 18 normal lung tissue. Results The positive rates of p-AKT was 53.8% in NSCLC and 0.0 in normal lung tissue(P 0.05).The expression of p-AKT was not related to age,sex,smoking,histological subtype,grade of cell differentiation,lymph node metastasis and TNM stage(P0.05). Conclusion The expression of p-AKT was higher in NSCLC than in normal tissue.The PI3K/AKT signaling pathway may participate in carcinogenesis and development of NSCLC.

Key concepts: Protein kinase B, Immunohistochemistry, Carcinogenesis, PI3K/AKT/mTOR pathway, Lung cancer, Stage (stratigraphy), Medicine, Oncology

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