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2003•The Practical Journal of CancerRequires access

Diagnostic Value of C-Myc and PCNA in Thyroid Neoplasm

Bo Luo

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Abstract

Objective To study the diagnostic value of c Myc and proliferating cell nuclear antigen(PCNA)in the benign and malignant thyroid neoplasms.Methods Expressions of C Myc and PCNA were detected in 28 thyroid adenomas and 30 thyroid carcinomas by immunohistochemical method.Results The positive rate of c Myc and PCNA was significantly higher in thyroid carcinoma than those in thyroid adenoma(90.0% and 80.0% VS 42.9% and 53.6%,respectively)( P 0.05).C Myc was mainly located in nuclear of tumor cells in thyroid adenomawith a positive rate of 83.3%.,while c Myc was mainly located in cytoplasm of tumor cells in thyroid carcinoma,with a positive rate of 88.9%.No correlation was observed between c Myc and PCNA expression in thyroid neoplasm.Conclusion The detection of c My and PCNA is valuable to differentiate between benign and malignant neoplasm of thyroid gland,and there is no synergy between c Myc and PCNA expression in thyroid neoplasm.

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Objective To study the diagnostic value of c Myc and proliferating cell nuclear antigen(PCNA)in the benign and malignant thyroid neoplasms.Methods Expressions of C Myc and PCNA were detected in 28 thyroid adenomas and 30 thyroid carcinomas by immunohistochemical method.Results The positive rate of c Myc and PCNA was significantly higher in thyroid carcinoma than those in thyroid adenoma(90.0% and 80.0% VS 42.9% and 53.6%,respectively)( P 0.05).C Myc was mainly located in nuclear of tumor cells in thyroid adenomawith a positive rate of 83.3%.,while c Myc was mainly located in cytoplasm of tumor cells in thyroid carcinoma,with a positive rate of 88.9%.No correlation was observed between c Myc and PCNA expression in thyroid neoplasm.Conclusion The detection of c My and PCNA is valuable to differentiate between benign and malignant neoplasm of thyroid gland,and there is no synergy between c Myc and PCNA expression in thyroid neoplasm.

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Available abstract

Objective To study the diagnostic value of c Myc and proliferating cell nuclear antigen(PCNA)in the benign and malignant thyroid neoplasms.Methods Expressions of C Myc and PCNA were detected in 28 thyroid adenomas and 30 thyroid carcinomas by immunohistochemical method.Results The positive rate of c Myc and PCNA was significantly higher in thyroid carcinoma than those in thyroid adenoma(90.0% and 80.0% VS 42.9% and 53.6%,respectively)( P 0.05).C Myc was mainly located in nuclear of tumor cells in thyroid adenomawith a positive rate of 83.3%.,while c Myc was mainly located in cytoplasm of tumor cells in thyroid carcinoma,with a positive rate of 88.9%.No correlation was observed between c Myc and PCNA expression in thyroid neoplasm.Conclusion The detection of c My and PCNA is valuable to differentiate between benign and malignant neoplasm of thyroid gland,and there is no synergy between c Myc and PCNA expression in thyroid neoplasm.

Key concepts: Proliferating cell nuclear antigen, Thyroid, Thyroid neoplasm, Immunohistochemistry, Neoplasm, Thyroid carcinoma, Thyroid tumors, Adenoma

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