Analysis on Distribution and Drug Resistance of 98 Strains of Staphylococcus aureus

Objective To analyze the drug resistance of Staphylococcus aureus isolated from the patients in the People's Hospital of Guiyang County in the last two years,and to provid a basis for rational use of antimicrobial agents in clinic.Methods Identification and antimicrobial susceptibility test of Staphylococcus aureus were determined with TDR-200B Microbiological Analysis System.The results were analyzed by WHONET5.3 software.Results Among the 98 strains of Staphylococcus aureus,65 strains(66.3%) were methicillin-resistant Staphylococcus aureus(MRSA),mainly from sputum,wound exudates and pus,etc.The detected MRSA were sensitive to vancomycin and teicoplanin.Their resistance rates to chloramphenicol,minocycline and rifampin were 24.6%,27.7% and 52.3% respectively.The drug resistance rates of MRSA to other antimicrobial agents were all greater than 80% and were higher than those of methicillin-susceptible Staphylococcus aureus.Conclusions Among Staphylococcus aureus isolated in clinic,MRSA has high resistance rates to many antimicrobial agents.Many MRSA strains are multi-drug resistant.The drug resistance of MRSA should be closely monitored in laboratories for the benefit of rational use of antimicrobial agents in clinic.