The expression and interrelationship between bFGF and VE GF in rats following brain injury

Objectiv e To study the expressions and interrelationship between bFGF and VEG F in different brain injuried areas and with the model. To investigate the patho genic mechanism of brain injury at molecular level and explore potential effective treatment for the dysfunction. MethodsUsing the modified Marmarou's rode nt model of impact acceleration diffuse brain injury,48 Spranue-Dawley(SD) rats were randomizly d ivided into eight groups (every group n =6). The immunological positive of bFGF,VEG F were observed in these rats using the method of immunohistochemical stain and histopathological HE staining. ResultsThe expression of bFGF mRNA was increased in the cortices in 1hr postinjury and peaked at 12h in marginal areas of injured focus. The expression of VEGF mRNA was increased following brain injury and peak ed at 24h in marginal areas of focal brain injury,returned down to normal at 7 2h. ConclusionThere is a closer relationship between bFG F,VEGF gene expression and the degree of brain injury. As a neurotrophic factor ,bFGF may contribute to neuroprotective effects against injury and repairing following brain injury.