Effects of zinc on the growth and the thyroid function in rats with iodine deficiency

Objective To observe the effects of zine(Zn) on the growth,the morphology and function of thyroid in the different iodine levels of rats. Methods Wistar rats with iodine deficiency were duplicated with fodder of Iodine Deficiency Disorder(IDD) areas and iodine,compound zine(Zn C) ,Zine ghiconate(Zn G) and iodine added compound zinc were given in rats of other 5 groups with iodine deficiency for 3 months.The weight of rats in groups was weighed in a week;lodine(I) in the urine were measured and the changes of the weight. the fine - structure of thyroid and the levels thyroid hormone were observed in 3 months. Results In the groups of iodine deficeney and Zn- supplementation,I in urine decreased. The slowness in the increase of weight and goiter were observed. There was an increase of Te, FT3 and a decrease of T4 , FT4 in the iodine deficiency group . The conditions of the growth in groups were similar to that in aliministration of I group. In 2 groups of Zn administration, the wetght of thyroid were lowered than that in the group of I deficiency and thyroid hormone restored in the degree. Conclusion Zn supplementation could promote the growth, decrease the degree of goiter and adjust the disorder of thyroid hormone in the rats of I deficiency.