Clinical effect of quetiapine combined with sodium valproate in the treatment of bipolar disorder manic

Objective To observe the effectiveness and safety of quetiapine combined with sodium valproate in the treatment of bipolar disorder manic. Methods From March 2012 to March 2014,80 patients with bipolar disorder manic treated in our hospital were selected and randomly divided into the research group(n=40) and control group(n=40).The control group was given quetiapined,while the research group was given quetiapine combined with sodium valproate.The course of treatment lasted 8 weeks.The therapeutic effect was evaluated by Bech-Rafaelsen mania scale(BRMS).The total effective rate,the incidence rate of adverse reaction in the two groups were compared. Results After 4,8 weeks treatment,BRMS score of the research group was greatly lower than that in the control group with a statistical difference(P 0.05). After 8 weeks treatment,there was no statistical difference of the total effective rate in the two groups(P 0.05). There was a statistical difference of the incidence rate of adverse reaction in the two groups(P 0.05).Conclusion Quetiapine combined with sodium valproate in the treatment of bipolar disorder manic obtains a definite therapeutic effect.It is safe and reliable,and is worthy of clinical expansion and application.