The Effect of ZhongFeiHeJi Regulate the TGF-β1 IL-6 and IL-1 Expression in Peripheral Blood of Rats with Radioactive Injury of Lungs

Objective:To research the effect that the ZhongFeiHeJi to influence the level of TGF–β1、IL-6 and IL-1 in peripheral blood of rats with radioactive injury of lungs.Methods:The rats in ZhongFeiHeJi group were poured with ZhongFeiHeJi after 90 Wistar rats were randomly divided into the normal group,the model group,the ZhongFeiHeJi group,and the rat model of radiation-induced pulmonary injury was copied by radiated with 6MV-X ray linear accelerator for 25Gy dose. After 8 weeks,the concentration of the cytokine such as TGF-β,IL-1,IL-6 in blood serum with the methods of enzyme-linked immunosorbent assay.Results:The survival rate of rats in the ZhongFeiHeJi group wasn't elevated than them in the model group,and the expressing level of TGF–β1 and IL-6 in the ZhongFeiHeJi group was lower than then in the model group(P0.01),but the ZhongFeiHeJi group without obvious effect on the level of IL-1 compare with the model group.Conclusion:ZhongfeiHeJi can improve the live quality of rats by to regulating excreting of cytokine,and have the preventive and therapeutic effect on the rats with radioactive injury of lungs.