Peritoneal Dialysis for Acute Renal Failure Following Cardiac Surgery of Infants with Complicated Congenital Heart Disease and Its Relationship with C-reactive Protein

Objective To investigate the therapeutic effects of peritoneal dialysis(PD)on acute renal failure following cardiac surgery of infants with complicated congenital heart disease and its relationship with C-reactive protein(CRP).Methods From January 2007 to January 2009,18 infants who underwent peritoneal dialysis because of acute renal failure following cardiac surgery of infants with complicated congenital heart disease were analyzed.Before PD and the 1st day after the end of PD,the changes of blood urea,serum creatinine,potassium,sodium,calcium,carbon dioxide combining power(CO2CP),mean arterial pressure,CPR and urine volume were detected.Results There were 2 patients who died of multiple organ failure,mortality was 11.1%.There was no common complication of peritoneal dialysis such as peritonitis,blockage of peritoneal dialysis tube,bleeding.The levels of CRP of the survival patients per-PD and post-PD were higher than normal(8 mg/L).Compared with pre-PD,blood urea,serum creatinine,potassium and CRP of post-PD decreased remarkably(P0.01),CO2CP,mean arterial pressure and urinary volume of post-PD increased evidently(P0.01),no obvious change was found in levels of serum sodium and calcium(P0.05).The range of decreased CRP was positively correlated with the ranges of decreased blood urea and serum creatinine(r1=0.747,P0.01;r2=0.515,P0.05),and not correlated with changes of urinary volume and ultrafiltration volume,range of decreased potassium,range of increased mean arterial pressure(r=-0.062,0.377,0.443,0.198,P0.05).Conclusion Peritoneal dialysis is an effective and safe method for treating acute renal failure after cardiac operation in infants with complicated congenital heart disease.C-reactive protein increases in acute renal failure after cardiac operation in infants.Amelioration of CRP by peritoneal dialysis maybe relates with clearance of blood urea and serum creatinine,while does not relate with changes of ultrafiltration,electrolytes,mean arterial pressure and urinary volume.