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2006•Di-Si Junyi Daxue xuebaoRequires access

Clinicopathological analysis of 45 cases of gastrointestinal stromal tumor

Run Zhang

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Abstract

AIM: To explore the clinicopathology of gastrointestinal stromal tumor(GIST)and its immunohistochemical features. METHODS: Observation and contrast analysis were made after the routine check and immunohistochemical staining in 45 GIST cases. RESULTS: GIST cells were more abundant than the typical leiomyoma cells and presented spindle-shaped or epithelioid, or a coexistence of spindle-shaped or epithelioid cells; in cytoplasm, the acidophilia decreased, and vacuoles were found arranged like intertexture, widespread lamellar, palisade or wheel radiation;typical cell nesting was formed;stroma or vessel wall showed a hyaline degeneration. CONCLUSION: GIST possesses unique histomorphological characteristics and the combination of CD117 and CD34 was helpful to differential diagnosis.

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What this paper is about

AIM: To explore the clinicopathology of gastrointestinal stromal tumor(GIST)and its immunohistochemical features. METHODS: Observation and contrast analysis were made after the routine check and immunohistochemical staining in 45 GIST cases. RESULTS: GIST cells were more abundant than the typical leiomyoma cells and presented spindle-shaped or epithelioid, or a coexistence of spindle-shaped or epithelioid cells; in cytoplasm, the acidophilia decreased, and vacuoles were found arranged like intertexture, widespread lamellar, palisade or wheel radiation;typical cell nesting was formed;stroma or vessel wall showed a hyaline degeneration. CONCLUSION: GIST possesses unique histomorphological characteristics and the combination of CD117 and CD34 was helpful to differential diagnosis.

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Available abstract

AIM: To explore the clinicopathology of gastrointestinal stromal tumor(GIST)and its immunohistochemical features. METHODS: Observation and contrast analysis were made after the routine check and immunohistochemical staining in 45 GIST cases. RESULTS: GIST cells were more abundant than the typical leiomyoma cells and presented spindle-shaped or epithelioid, or a coexistence of spindle-shaped or epithelioid cells; in cytoplasm, the acidophilia decreased, and vacuoles were found arranged like intertexture, widespread lamellar, palisade or wheel radiation;typical cell nesting was formed;stroma or vessel wall showed a hyaline degeneration. CONCLUSION: GIST possesses unique histomorphological characteristics and the combination of CD117 and CD34 was helpful to differential diagnosis.

Key concepts: GiST, CD117, Pathology, CD34, Hyaline, Immunohistochemistry, Stromal tumor, Stromal cell

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