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2000•Journal of Postgraduates of MedicineRequires access

EXPRESSION OF P16 PROTEIN AND ITS CLINICAL IMPLICATION IN THE CARCINOGENESIS OF HUMAN COLORECTAL CARCINOMA

Hong Zhang, Dong Chen, Jian-ye He, Shuyun Li, Dongling Gao

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Abstract

Objective:To investigate the expression of p16 protein in human colorectal carcinoma and its clinical implication.Method:The expression of p16 protein was determined by immunohistochemical method in 30 cases of human colorectal carcinoma,and compared with that in adenoma and normal mucosa.Results:The positive rates of p16 protein expression in the 30 cases were 40.0%.The expression level of p16 in cancerous tissue is lower than that in normal mucosa and adenoma (P0.05).The positive rates of p16 expression in different pathological gradings\,post-operative survival (3 years) and lymph node metastasis showed significant difference(P0.05).Conclutions:The deletion and mution of p16 protein exist in human colorectal carcinoma,and p16 protein plays and important role in proliferation and differentiation of colorectal carcinoma.

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What this paper is about

Objective:To investigate the expression of p16 protein in human colorectal carcinoma and its clinical implication.Method:The expression of p16 protein was determined by immunohistochemical method in 30 cases of human colorectal carcinoma,and compared with that in adenoma and normal mucosa.Results:The positive rates of p16 protein expression in the 30 cases were 40.0%.The expression level of p16 in cancerous tissue is lower than that in normal mucosa and adenoma (P0.05).The positive rates of p16 expression in different pathological gradings\,post-operative survival (3 years) and lymph node metastasis showed significant difference(P0.05).Conclutions:The deletion and mution of p16 protein exist in human colorectal carcinoma,and p16 protein plays and important role in proliferation and differentiation of colorectal carcinoma.

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Available abstract

Objective:To investigate the expression of p16 protein in human colorectal carcinoma and its clinical implication.Method:The expression of p16 protein was determined by immunohistochemical method in 30 cases of human colorectal carcinoma,and compared with that in adenoma and normal mucosa.Results:The positive rates of p16 protein expression in the 30 cases were 40.0%.The expression level of p16 in cancerous tissue is lower than that in normal mucosa and adenoma (P0.05).The positive rates of p16 expression in different pathological gradings\,post-operative survival (3 years) and lymph node metastasis showed significant difference(P0.05).Conclutions:The deletion and mution of p16 protein exist in human colorectal carcinoma,and p16 protein plays and important role in proliferation and differentiation of colorectal carcinoma.

Key concepts: Medicine, Immunohistochemistry, Pathological, Adenoma, Lymph node metastasis, Carcinogenesis, Colorectal cancer, Cancer research

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EXPRESSION OF P16 PROTEIN AND ITS CLINICAL IMPLICATION IN THE CARCINOGENESIS OF HUMAN COLORECTAL CARCINOMA — Research Paper | ScholarLens