Association of serum uric acid level with coronary lesions

Objective To explore the association of serum uric acid(UA) level with the severity and stability of coronary lesions.Methods Among 454 patients,294 confirmed main or branch vessel stenosis ≥ 50% by coronary angiography were regarded as observation group,and 160 patients with stenosis 50% were regarded as control group.According to the clinical type,the observation group was divided into stable angina group,acute coronary syndrome group(unstable angina,acute myocardial infarction),and it was divided into single-vessel disease group,double vessel disease group,and multivessel disease group.Parallel Gensini score were performed and blood uric acid,glucose,lipids,liver and kidney function and other biochemical differences were compared.Results Serum uric acid level in observation group was significantly higher,HDL level was lower and LDL levels was higher than those in the control group;uric acid levels in coronary heart disease and two-branch and multi-vessel disease were significantly higher than that in the single-vessel disease and the control group;blood uric acid levels in patients with acute coronary syndrome were significantly higher than that in the patients with stable angina and control groups,the differences were statistically significant(P0.05 and(P0.01).Gensini score in patients with coronary heart disease had positive linear correlation with serum uric acid level,and stepwise Logistic regression analysis showed that the effect of uric acid for coronary heart disease was statistically significant(P 0.05).Conclusion Higher serum uric acid may be an independent risk factor of CHD,it was close related to the severity and stability of coronary stenosis.Early intervention of the elevated serum uric acid may delay the development of CHD and improve its prognosis.