2015•The Chinese Journal of Clinical PharmacologyRequires access
Study on the association between expression of serum squqmous cell carcinoma antigen,carbohydrate antigen 125 and cervical carcinoma stage
Jinhu Wang
Open publisher page 0 citations
Abstract
Objective To evaluate the association between expression of serum squamous cell carcinoma antigen( SCC- Ag),carbohydrate antigen 125( CA125) and cervical carcinoma stage. Methods The serum level of SCC- Ag and CA125 were retrospectively analyzed in the included 338 cases with stage of I- Ⅳ cervical carcinoma. The association between serum level of SCC- Ag,CA125 207 and clinical pathology features were further analyzed in 207 cases who received surgery.Results The serum level of SCC- Ag was significantly increased with the development of clinical states in patients with squamous cell cervical carcinoma( P 0. 05). By analyzing the 207 cases who received surgery,we found that the serum level of SCC- Ag was significantly increased with the development of tumor volume( P 0. 05),lymph node metastasis( P 0. 05) and invasion( P 0. 05). Meanwhile,after surgery,the serum level of SCC- Ag were significantly decreased compared to prior treatment( P 0. 05). The serum level of CA125 was not associated with the clinical stage( P 0. 05). Conclusion Serum level of SCC- Ag can be an important bio- marker for the evaluation of clinical stages and pathology features of patients with squamous cervical carcinoma.