ScholarLens Back to search
2001•Zhongguo laonianxue zazhiRequires access

Amyloid-β protein 40 and the expression of IL-1α in the SD rat brains

Shao Jun

Open publisher page 0 citations

Abstract

Objective To study whether Aβ40 can induce the expression of IL 1α in the rat brain.Methods IL 1α expression was assayed by immunostaining of formalin fixed brain sections.Results There were positive IL 1α staining in the formalin fixed hippocampal sections of the rats injected with Aβ40.In contrast,IL 1α immunoreaction was not detectable in the brains of control rats.Conclusions It indicates that Aβ40 can induce IL 1α expression in the brain of the SD rats It suggests that IL 1α may be mediators in the pathological process of AD.

About this research paper

What this paper is about

Objective To study whether Aβ40 can induce the expression of IL 1α in the rat brain.Methods IL 1α expression was assayed by immunostaining of formalin fixed brain sections.Results There were positive IL 1α staining in the formalin fixed hippocampal sections of the rats injected with Aβ40.In contrast,IL 1α immunoreaction was not detectable in the brains of control rats.Conclusions It indicates that Aβ40 can induce IL 1α expression in the brain of the SD rats It suggests that IL 1α may be mediators in the pathological process of AD.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To study whether Aβ40 can induce the expression of IL 1α in the rat brain.Methods IL 1α expression was assayed by immunostaining of formalin fixed brain sections.Results There were positive IL 1α staining in the formalin fixed hippocampal sections of the rats injected with Aβ40.In contrast,IL 1α immunoreaction was not detectable in the brains of control rats.Conclusions It indicates that Aβ40 can induce IL 1α expression in the brain of the SD rats It suggests that IL 1α may be mediators in the pathological process of AD.

Key concepts: Immunostaining, Hippocampal formation, Staining, Pathological, Immunohistochemistry, Amyloid (mycology), Pathology, Positive staining

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Amyloid-β protein 40 and the expression of IL-1α in the SD rat brains — Research Paper | ScholarLens