Hemostatic efficacy of fibrin dressing

Objective To evaluate the hemostatic efficacy of fibrin dressing in animal models of femoral artery transection and liver injury. Methods Fibrin dressing and collagen sponge were used in Wistar rat femoral artery incision and rabbit partial liver resections. The time to achieve complete hemostasis was recorded for each animal, as well as the blood loss. Results In femoral artery injury model, hemostasis occurred (90.60±33.12) s later in the fibrin dressing group, with the blood loss of (0.51±0.26) ml. In the collagen sponge group, hemostasis occurred (164.20±53.70) s later, with the blood loss of (1.04±0.50)ml. Statistical analysis showed significant difference between these two groups (P0.05). In liver injury model, hemostasis occurred (48.67±8.14) s later in the fibrin dressing group, with blood loss of (0.82±0.09) ml. In the collagen sponge group, hemostasis occurred (107.67±6.66) s later, with the blood loss of (1.07±0.13) ml. Statistical analysis showed significant difference between these two groups (P0.05). Conclusion The hemostatic effect of fibrin dressing is better than collagen sponge, and fibrin dressing is a good topical hemostatic .