Significance and Expression of Vascular Endothelial Growth Factor-C and Microvessel Density in Breast Cancer

This paper investigates the relationship between Vascular Endothelial Growth Factor(VEGF)-C tumor angiogenesis and biological behavior in primary breast cancer.The immunohistochemical PV9000 technique was adopted in detecting the VEGF-C protein and Microvessel Density expression in 50 cases of primary breast cancer.The results show that the VEGF-C and MVD expression in the group with lymph node metastasis is significantly higher than that in the group without lymph node metastasis(p0.05).The level of MVD in the group of VEGF-C-positive expression is 31.67±7.85,while in the group of VEGF-C-negative expression is 26.84±7.03.The difference between them was significant(p0.05).It is concluded that the VEGF-C mainly promotes breast tumor lymph angiogenesis and has a little effect on angiogenesis.Clinical significance was found between VEGF-C,MVD expression and lymph-node metastasis in breast cancer,which may involve a metastatic process.