2010•China Medical HeraldRequires access

Analysis on the 228 Mycobacterium Tuberculosis with MLVA

Wan Kang-lin

Abstract

Objective:By Multiple locus variable numbers of tandem repeats(MLVA) genotyping,to analyze the genotypes of epidemic Mycobacterium tuberculosis strains in Gansu. Methods:15 standardized MLVA loci were used to type the clinical isolated M. tuberculosis strains of Gansu. Results were analyzed with BioNumerics 4.5. The dendrogram was summarized from the fingerprintings. Results:The result of MLVA showed that 228 strains of M. tuberculosis were classified 4 major genetic groups and 7 main genotypes. The largest genotype included 171(75.0%) strains,the others were 13(5.7%) ,3(1.3%) ,7(3.1%) ,1(0.4%) ,31(13.6%) and 2(0.9%) respectively. Farther particulars,93 strains(40.8%) were belong to unique genotype. The other strains contained 2-10 M. tuberculosis,all 132 geno-clusters. Conclusion:The bacterium strains of M. tuberculosi in Gansu has a rich nucleotide polymorphisms. MLVA is very useful to type the genotype of M. tuberculosi strains. Beijing family genotype strain is the dominant genotype in Gansu.

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Key concepts: Multiple Loci VNTR Analysis, Genotype, Genotyping, Mycobacterium tuberculosis, Variable number tandem repeat, Tuberculosis, Medicine, Tandem repeat