The Prognostic Analysis of the Therapeutics of Cytokine induced Killer Cells on the Patients with Advanced Non Small Cell Lung Cancer

Objective It is to investigate the cytotoxicity in vitro of cytokine-induced killer(CIK) cells after coculturing,and to observe their clinical antitumour efficacy,immunological activity.Methods Peripheral blood mononuclear cells(PBMC) were isolated from 20 patients with advanced non small cell lung cancer,who had been treated with standard protocol.CIK cells were induced and coculture in vitro.The phenotypes changes of CIK cells were identified by flow cytometric analysis.20 patients were treated with CIK cells for immunotherapy,and we evaluated their clinical antitumour efficacy,immunological activity and survival instances of them.Results The survival of the experiment group was(16.15±3.8)months,while the other group was(9.12±3.2)months,which was statistically significantly different(P 0.05).Conclusion CIK is effective to advanced non small cell lung cancer and it can imp rove the prognosis of them.