Clinical study on Alprostadil Injection combined with Niaoduqing Granules in treatment of chronic renal insufficiency

Objective To investigate the effect of Alprostadil Injection combined with Niaoduqing Granules in the treatment of chronic renal insufficiency. Methods Collecting 40 cases suffered from chronic renal insufficiency from July 2012 to February 2014 in the Authority Hospital of Jinan City, which were randomly divided into treatment(20 cases) and control(20 cases) group. Patients in the control group were po administered with Niaoduqing Granules on the basis of foundation treatment, 1 bag/time, three times daily. Patients in the treatment group were iv administered with Alprostadil Injection 10 μg/d for more than 3 h on the basis of control group. The patients in the two groups were treated for 3 weeks. After the treatment, the treatment efficacy was evaluated, while Scr, Ccr, BUN, Hb, Alb, and regulatory T cell were compared between the two groups. Results The efficacies in the treatment and control groups were 75.0% and 65.0%, respectively, and there were differences between the two groups(P 0.05). After the treatment, BUN and Scr in the two groups were significantly reduced, while the Ccr and Hb were significantly increased, and the difference was statistically significant before and after the treatment in the same group(P 0.05, 0.01). And after the treatment, BUN, Scr, and Ccr in the treatment group were improved better than those in the control group, and there was significant difference between the two groups(P 0.05). After the treatment, CD4+-Treg and CD4+CD25+CD127-Treg in the two groups were significantly reduced, and the difference was statistically significant before and after the treatment in the same group(P 0.05). And reduced degree in the treatment group was greater than that in the control group, and there was significant difference between the two groups(P 0.05, 0.01). Th1 and Th1/Th2 in the two groups were significantly increased, while Th2 was significantly reduced, and the differenc was statistically significant before and after the treatment in the same group(P 0.01). After the treatment, Th1 and Th1/Th2 in the treatment group were significantly higher than those in the control group, and there was significant difference between the two groups(P 0.05). Conclusion Alprostadil Injection combined with Niaoduqing Granules has a good clinical effect in the treatment of chronic renal insufficiency, which maybe through adjust the immune function of patients and improve the levels of Th1/Th2 to play the role.