Advance in Animal Models of Transgenic Diseases

The animal model of human disease is made for expounding the occurring mechanism of human disease or the establishment of treatment method,which has the experimental animal which human disease simulates the performance. Disease animal model has made big contribution to the medicine development. But, for many diseases it is very difficult to make animal models with some artificial method,perhaps some diseases do not occur in the experimental animals or only occur in human,Therefore,it is difficult to obtain the animal model through spontaneous or the artificial directed breeding method. With the development of transgenic technology, it is possibile to study the correlation between gene and the disease, moreover people might use any individual at each stage of ontogenesis to carry on the analysis of heredity function. Therefore, the study and development of animal models for transgenic disease are very important.The establishing mechanism and prospects of development and utilization of animal models for transgenic disease were summarized in this article.