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2002•Journal of Tongji UniversityRequires access

The Effects of Oxygen Free Radicals on Lung Injury from Intestinal Ischemia-Reperfusion in Rats

He Zhong

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Abstract

Objective To investigate the relationship between oxygen free radicals and lung injury from intestinal ischemia reperfusion and oxygen free radicals in rats.Methods 24 adult male SD rats were randomly divided into three groups ( n =8),such as sham operation,intestinal ischemia,and intestinal ischemia reperfusion (IIR).The pulmonary microvascular permeability and the levels of malondialdehyde (MDA),superoxide dismutase (SOD) of the plasma and lung tissue of each group were measured.Results Comparing with the other two groups,the level of oxygen free radicals and microvascular permeability in the lung tissue of IIR group were increased significantly.MDA correlated with pulmonary microvascular permeability of the IIR group.Conclusion The level of oxygen free radicals increased significantly in IIR rats,and it may be involved in the pathogenesis of lung injury caused by intestinal ischemia reperfusion in rats.

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Objective To investigate the relationship between oxygen free radicals and lung injury from intestinal ischemia reperfusion and oxygen free radicals in rats.Methods 24 adult male SD rats were randomly divided into three groups ( n =8),such as sham operation,intestinal ischemia,and intestinal ischemia reperfusion (IIR).The pulmonary microvascular permeability and the levels of malondialdehyde (MDA),superoxide dismutase (SOD) of the plasma and lung tissue of each group were measured.Results Comparing with the other two groups,the level of oxygen free radicals and microvascular permeability in the lung tissue of IIR group were increased significantly.MDA correlated with pulmonary microvascular permeability of the IIR group.Conclusion The level of oxygen free radicals increased significantly in IIR rats,and it may be involved in the pathogenesis of lung injury caused by intestinal ischemia reperfusion in rats.

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Available abstract

Objective To investigate the relationship between oxygen free radicals and lung injury from intestinal ischemia reperfusion and oxygen free radicals in rats.Methods 24 adult male SD rats were randomly divided into three groups ( n =8),such as sham operation,intestinal ischemia,and intestinal ischemia reperfusion (IIR).The pulmonary microvascular permeability and the levels of malondialdehyde (MDA),superoxide dismutase (SOD) of the plasma and lung tissue of each group were measured.Results Comparing with the other two groups,the level of oxygen free radicals and microvascular permeability in the lung tissue of IIR group were increased significantly.MDA correlated with pulmonary microvascular permeability of the IIR group.Conclusion The level of oxygen free radicals increased significantly in IIR rats,and it may be involved in the pathogenesis of lung injury caused by intestinal ischemia reperfusion in rats.

Key concepts: Malondialdehyde, Superoxide dismutase, Radical, Ischemia, Lung, Reperfusion injury, Oxygen, Pathogenesis

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