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2011•Chinese Journal of Birth Health & HeredityRequires access

The genetics analysis in 208 male infertile patients

HE Xi-y

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Abstract

Objective:To analyse the 208 male infertile patients in genetics and explore the relationship between chromosomal abnormalities and Y chromosome microdeletions in male infertile patients.Methods:Karyotypic anlaysis and multiplicitas PCR were carried out in 208 male infertile patients for chromosome karyotype and the analysis of AZF in Y chromosome.Results:Of the 208 patients,36(17.31%)were found to have chromosome abnormalities and 8(3.84%)were found to have Y chromosome microdeletions.Conclusion:The chromosomal abnormalities and Y chromosome microdeletions may play an important role in male infertility,suggesting the importance of examinations of chromosomal abnormalities and Y chromosome microdeletions in diagnosis and genetic screening of such patients.

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What this paper is about

Objective:To analyse the 208 male infertile patients in genetics and explore the relationship between chromosomal abnormalities and Y chromosome microdeletions in male infertile patients.Methods:Karyotypic anlaysis and multiplicitas PCR were carried out in 208 male infertile patients for chromosome karyotype and the analysis of AZF in Y chromosome.Results:Of the 208 patients,36(17.31%)were found to have chromosome abnormalities and 8(3.84%)were found to have Y chromosome microdeletions.Conclusion:The chromosomal abnormalities and Y chromosome microdeletions may play an important role in male infertility,suggesting the importance of examinations of chromosomal abnormalities and Y chromosome microdeletions in diagnosis and genetic screening of such patients.

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Available abstract

Objective:To analyse the 208 male infertile patients in genetics and explore the relationship between chromosomal abnormalities and Y chromosome microdeletions in male infertile patients.Methods:Karyotypic anlaysis and multiplicitas PCR were carried out in 208 male infertile patients for chromosome karyotype and the analysis of AZF in Y chromosome.Results:Of the 208 patients,36(17.31%)were found to have chromosome abnormalities and 8(3.84%)were found to have Y chromosome microdeletions.Conclusion:The chromosomal abnormalities and Y chromosome microdeletions may play an important role in male infertility,suggesting the importance of examinations of chromosomal abnormalities and Y chromosome microdeletions in diagnosis and genetic screening of such patients.

Key concepts: Karyotype, Y chromosome microdeletion, Male infertility, Chromosome, Biology, Y chromosome, Genetics, Chromosome analysis

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