2009•Yaowu fenxi zazhiRequires access

Evaluation of uncertainty for the determination of cefuroxime reference substance by HPLC

Yuanchao Xie

Abstract

Objective:To establish a method of uncertainty evaluation for the determination of cefuroxime reference substance by HPLC.Methods:The uncertainty was evaluated by a established mathematical model and the analysis of various factors affecting sample detection.Results:Each component of uncertainty was calculated and then the combined uncertainty was finally obtained by synthesizing the uncertainties of various component variables.Conclusion:This method is appropriate to be used in the uncertainty evaluation for the determination of cefuroxime reference substance by HPLC.

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Available abstract

Key concepts: Cefuroxime, Chemistry, Chromatography, High-performance liquid chromatography, Measurement uncertainty, Component (thermodynamics), Uncertainty analysis, Statistics