Clinical study of retinal nerve fiber layer thickness in myopia using optical conhenrence tomography

Objective To study the characteristics and clinical significance of retinal nerve fiber layer(RNFL)thickness with an increasing myopia degree.Methods According to the myopia degree,150 subjects were divided into 4 groups:normal,slight,medium and high myopia groups.Optical conhenrence tomography(OCT)was used to measure the RNFL thickness.Each subject was performed circular scans around the optic nerve with a circle size of 3.46 mm.The mean and different quadrants RNFL thickness in different groups were analyzed.Results The mean RNFL thickness of normal,slight,medium and high myopia group was(123.74±35.68)μm,(119.33±37.23)μm,(117.84±36.57)μm,(112.89±37.09)μm,respectively.Compared with normal groups,the mean RNFL thickness in myopia groups was thinner,but only high myopia groups presented significantly thinner.The change occurred first in nasal quadrant.RNFL thickness in high myopia group was significantly thinner in nasal,inferior and superior quadrant,while significantly thicker in temporal quadrant.Conclusion The mean RNFL thicknesses in myopia groups are thinner and thinner with an increase of myopia degree.Different with other quadrants,RNFL thickness in temporal quadrant was thicker.The result maybe shows characteristics of RNFL thickness in myopia groups,which is of instrctive significance to guide the diagnosis of the disease.