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Changes of matrix metalloproteinase-9 on severe acute pancreatitis complicated with lung injury in rats

Wei Bi

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Abstract

Objective To investigate the effect of matrix metalloproteinase-9(MMP-9) on severe acute pancreatitis(SAP) complicated with lung injury.Methods SAP was induced in SD rats by injecting 5% sodium taurocholate(0.15 ml/100 g) under pancreatic capsule.The SD rats were randomly divided into two groups:control group(n=12) and SAP group(n=12).The wet weigh index of lung,serum amylase level,the number of cells,quantity of protein in bronchoalveolar lavage fluid and MMP-9 levels in lung were detected at 12 hours after SAP models were set up.Results The wet weigh index of lung,serum amylase level,the number of cells,quantity of protein and the levels of MMP-9 in lung were all increased in rats of SAP group,as compared with those of control group(P0.05).Conclusion MMP-9 is released greatly in SAP,which is closely related with SAP complicated with lung injury.

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What this paper is about

Objective To investigate the effect of matrix metalloproteinase-9(MMP-9) on severe acute pancreatitis(SAP) complicated with lung injury.Methods SAP was induced in SD rats by injecting 5% sodium taurocholate(0.15 ml/100 g) under pancreatic capsule.The SD rats were randomly divided into two groups:control group(n=12) and SAP group(n=12).The wet weigh index of lung,serum amylase level,the number of cells,quantity of protein in bronchoalveolar lavage fluid and MMP-9 levels in lung were detected at 12 hours after SAP models were set up.Results The wet weigh index of lung,serum amylase level,the number of cells,quantity of protein and the levels of MMP-9 in lung were all increased in rats of SAP group,as compared with those of control group(P0.05).Conclusion MMP-9 is released greatly in SAP,which is closely related with SAP complicated with lung injury.

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Available abstract

Objective To investigate the effect of matrix metalloproteinase-9(MMP-9) on severe acute pancreatitis(SAP) complicated with lung injury.Methods SAP was induced in SD rats by injecting 5% sodium taurocholate(0.15 ml/100 g) under pancreatic capsule.The SD rats were randomly divided into two groups:control group(n=12) and SAP group(n=12).The wet weigh index of lung,serum amylase level,the number of cells,quantity of protein in bronchoalveolar lavage fluid and MMP-9 levels in lung were detected at 12 hours after SAP models were set up.Results The wet weigh index of lung,serum amylase level,the number of cells,quantity of protein and the levels of MMP-9 in lung were all increased in rats of SAP group,as compared with those of control group(P0.05).Conclusion MMP-9 is released greatly in SAP,which is closely related with SAP complicated with lung injury.

Key concepts: Medicine, Bronchoalveolar lavage, Lung, Acute pancreatitis, Amylase, Matrix metalloproteinase, Matrix metalloproteinase 9, Pancreatitis

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Changes of matrix metalloproteinase-9 on severe acute pancreatitis complicated with lung injury in rats — Research Paper | ScholarLens