ScholarLens Back to search
2004•Shanghai yufang yixueRequires access

Adverse effects of ultraviolet A on the growth of fibroblasts of human skin

NI Jiang-dong

Open publisher page 0 citations

Abstract

Objective To investigate the effects of UVA on the growth of fibroblasts of human skin and the mechanism of photoaging of fibroblasts. [Methods] Normal human fibroblasts were cultured from foreskins of healthy human. Photography,MTT spectrophotometry and LDH assay were applied to determine the damage of human skin fibroblasts irradiated by ultra violet A (UVA). [Results] With the increase close of UVA, fibroblasts became round and crimple from shuttle. At the dosage of 9 J/cm 2,the level of LDH rose from 56.82±4.78 U/dl to 120.40±7.16U/dl. At the dosage of 45 J/cm 2,inhibition rate of fibroblasts reached 67.12%. [Conclusion] UVA can induce damage to fibroblasts of human skin.

About this research paper

What this paper is about

Objective To investigate the effects of UVA on the growth of fibroblasts of human skin and the mechanism of photoaging of fibroblasts. [Methods] Normal human fibroblasts were cultured from foreskins of healthy human. Photography,MTT spectrophotometry and LDH assay were applied to determine the damage of human skin fibroblasts irradiated by ultra violet A (UVA). [Results] With the increase close of UVA, fibroblasts became round and crimple from shuttle. At the dosage of 9 J/cm 2,the level of LDH rose from 56.82±4.78 U/dl to 120.40±7.16U/dl. At the dosage of 45 J/cm 2,inhibition rate of fibroblasts reached 67.12%. [Conclusion] UVA can induce damage to fibroblasts of human skin.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To investigate the effects of UVA on the growth of fibroblasts of human skin and the mechanism of photoaging of fibroblasts. [Methods] Normal human fibroblasts were cultured from foreskins of healthy human. Photography,MTT spectrophotometry and LDH assay were applied to determine the damage of human skin fibroblasts irradiated by ultra violet A (UVA). [Results] With the increase close of UVA, fibroblasts became round and crimple from shuttle. At the dosage of 9 J/cm 2,the level of LDH rose from 56.82±4.78 U/dl to 120.40±7.16U/dl. At the dosage of 45 J/cm 2,inhibition rate of fibroblasts reached 67.12%. [Conclusion] UVA can induce damage to fibroblasts of human skin.

Key concepts: Human skin, Photoaging, Ultraviolet a, Fibroblast, Skin Aging, Ultraviolet b, Ultra violet, Ultraviolet irradiation

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Adverse effects of ultraviolet A on the growth of fibroblasts of human skin — Research Paper | ScholarLens