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2004•Journal of Jiangsu Clinical MedicineRequires access

EFFECTS OF Ad-HIF-1α ON APOPTOSIS FOLLOWING TRAUMATIC BRAIN INJURY

Pan Xin

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Abstract

Objective: To study the changes of apoptosis following Ad-HIF-1α-injected after the traumatic brain injury. Methods: A free-failing body device was used to produce traumatic brain injury. The expression of HIF-1αand Bcl-2 and Bax was detected with immunohistomistry method at different time points following traumatic brain injury. Results: The expression of Bcl-2 had decreased significantly, the expression of Bcl-2 was decteased significantly and the rate of apoptosis decreased in different time in Ad-HIF-1αgroup. Conclusions: Ad-HIF-1α-injected after traumatic brain injury can upregulate the expression of Bcl-2 and downregulate that of Bax to reduce cell death.

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What this paper is about

Objective: To study the changes of apoptosis following Ad-HIF-1α-injected after the traumatic brain injury. Methods: A free-failing body device was used to produce traumatic brain injury. The expression of HIF-1αand Bcl-2 and Bax was detected with immunohistomistry method at different time points following traumatic brain injury. Results: The expression of Bcl-2 had decreased significantly, the expression of Bcl-2 was decteased significantly and the rate of apoptosis decreased in different time in Ad-HIF-1αgroup. Conclusions: Ad-HIF-1α-injected after traumatic brain injury can upregulate the expression of Bcl-2 and downregulate that of Bax to reduce cell death.

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Available abstract

Objective: To study the changes of apoptosis following Ad-HIF-1α-injected after the traumatic brain injury. Methods: A free-failing body device was used to produce traumatic brain injury. The expression of HIF-1αand Bcl-2 and Bax was detected with immunohistomistry method at different time points following traumatic brain injury. Results: The expression of Bcl-2 had decreased significantly, the expression of Bcl-2 was decteased significantly and the rate of apoptosis decreased in different time in Ad-HIF-1αgroup. Conclusions: Ad-HIF-1α-injected after traumatic brain injury can upregulate the expression of Bcl-2 and downregulate that of Bax to reduce cell death.

Key concepts: Traumatic brain injury, Downregulation and upregulation, Apoptosis, Medicine, Programmed cell death, Biology, Psychiatry, Gene

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