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2007•Sichuan Journal of AnatomyRequires access

The Expression of TNF-a and IL-6 in Ethanol-Induced Rat Model

Cheng Dao-bang

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Abstract

Objective To abserve the change of TNF-α and IL-6 in the hepatic tissue of alcoholic fatty liver rats.Methods The rats with alcoholic fatty liver were given 56% alcohol by daily gavage,after 12 weeks,to observer the change of serum activities of alanine aminotransferase(ALT)and aspartate aminotransferase(AST),and the expression tumor necrosis factor(TNF)-α and interleukin(IL)-6 of hepatic tissue were observed.Results The model group rats'livers became more fatty and activities ascending of ALT and AST than normal and there was significant difference(P0.05).the contents of TNF-α and IL-6 in liver were higher than the normal group rats.Conclusion The increasing of TNF-α and IL-6 in liver tissue is possibly the one of the important mechanism for alcoholic fatty liver.

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What this paper is about

Objective To abserve the change of TNF-α and IL-6 in the hepatic tissue of alcoholic fatty liver rats.Methods The rats with alcoholic fatty liver were given 56% alcohol by daily gavage,after 12 weeks,to observer the change of serum activities of alanine aminotransferase(ALT)and aspartate aminotransferase(AST),and the expression tumor necrosis factor(TNF)-α and interleukin(IL)-6 of hepatic tissue were observed.Results The model group rats'livers became more fatty and activities ascending of ALT and AST than normal and there was significant difference(P0.05).the contents of TNF-α and IL-6 in liver were higher than the normal group rats.Conclusion The increasing of TNF-α and IL-6 in liver tissue is possibly the one of the important mechanism for alcoholic fatty liver.

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Available abstract

Objective To abserve the change of TNF-α and IL-6 in the hepatic tissue of alcoholic fatty liver rats.Methods The rats with alcoholic fatty liver were given 56% alcohol by daily gavage,after 12 weeks,to observer the change of serum activities of alanine aminotransferase(ALT)and aspartate aminotransferase(AST),and the expression tumor necrosis factor(TNF)-α and interleukin(IL)-6 of hepatic tissue were observed.Results The model group rats'livers became more fatty and activities ascending of ALT and AST than normal and there was significant difference(P0.05).the contents of TNF-α and IL-6 in liver were higher than the normal group rats.Conclusion The increasing of TNF-α and IL-6 in liver tissue is possibly the one of the important mechanism for alcoholic fatty liver.

Key concepts: Fatty liver, Internal medicine, Endocrinology, Alanine aminotransferase, Tumor necrosis factor alpha, Alcoholic fatty liver, Ethanol, Liver tissue

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