The research on the correlation between the level of serum IgE and IFN-γ and nasal mucosa eosinophil infiltration in Xinjiang Uyghur and Han patients with allergic rhinitis

Objective To evaluate the correlation between the level of serum IgE and IFN-γ and nasal mucosa eosinophilic infiltration in Xinjiang Uyghur and Han patients with allergic rhinitis. Methods By using double-antibody Enzyme-linked Immunosorbent Assay( ELISA),the level of serum IgE and IFN-γ in 62 Uyghur AR patients and 59 patients Han' s AR were analyzed,and pathology smear was observed and nasal smear mucosa eosinophil was counted under high-power microscope. Results There were not significantly difference in serum IgE and IFN-γ levels between Uyghur and Han patients with allergic rhinitis( t values were- 1. 208 and- 1. 205,P 0. 05),IgE levels and nasal mucosa eosinophil count were positively correlated( r values were 0. 583 and 0. 622,P 0.05),IFN-γ levels and nasal mucosa eosinophil count was negatively correlated( r values were- 0. 453,- 0. 526,P 0. 05). Conclusion There were not significantly differences in serum IgE and IFN-γ levels between Uyghur and Han patients with allergic rhinitis. IgE and IFN-γ play important roles in the course of AR in Xinjiang Uyghur and Han patients with allergic rhinitis. Expression of IgE and IFN-γ are associated with eosinophilic infillration in nasal mucosa.