Relationship between Gastric Acid and Stress Ulcer Produced by Water Immersion in Young Rats

Objective To establish the animal model with stress ulcer(SU) and probe the relationship between the gastric mucosal injury and lasting stress time,the dynamic structural changes of pH of gastric juice.Methods Twenty-four SD young rats were randomly divided into 4 groups:control group,45 min(groupⅠ),90 min(groupⅡ),3 h(groupⅢ)groups under water immersion restraint stress(WRS).The change of gastric mucosal ulcer index(UI),pH of gastric juice were observed.Results Acute gastric mucosal damage was induced by WRS,with the WRS time prolonged,UI increased gradually and pH of gastric juice remarkably decreased in experimental rats.UI was positively rela-ted with stress time(r=0.957 P0.01)but negatively with pH value(r=-0.852 P0.01).Conclusions It is found that gastric acid secretion increases progressively under stress conditions(P0.05),and the degree of gastric mucosal injury has a definite relation with lasting stress time,the occurrence and development of SU have a close correlation with pH of gastric juice.